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Genetic and Rare Diseases Information Center (GARD)

Palmoplantar keratoderma


Palmoplantar keratoderma (PPK) is a group of conditions characterized by thickening of the palms and soles of the feet. PPK can also be an associated feature of different syndromes.[1] In rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. PPK can either be inherited or acquired. Acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, or medications.[2] The hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They can be inherited in an autosomal dominant or autosomal recessive patterns.[1][2]
Last updated: 4/29/2011


  1. Lee RA & Elston DM. Keratosis Palmaris et Plantaris. eMedicine. July 2008; Accessed 4/29/2011.
  2. Palmoplantar keratoderma. DermNet. November 18, 2014; Accessed 4/29/2011.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • The Foundation for Ichthyosis Related Skin Types has a fact sheet on Palmoplantar Keratodermas (PPK). To view this page, click on the link.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Palmoplantar keratoderma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Keratoderma, Palmoplantar
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