Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Palmoplantar keratoderma


Newline Maker

How might palmoplantar keratoderma be treated?

Treatment of both hereditary and nonhereditary palmoplantar keratodermas is difficult. Treatment usually only results in short-term improvement and often has adverse side effects.[1] The goal of treatment is usually to soften the thickened skin and makes it less noticeable.[2] Treatment may include simple measures such as saltwater soaks, emollients, and paring. More aggressive treatment includes topical keratolytics, topical retinoids, systemic retinoids (acitretin), topical vitamin D ointment (calcipotriol), or surgery to removed the skin, following by skin grafting.[1][2]
Last updated: 4/29/2011

  1. Lee RA & Elston DM. Keratosis Palmaris et Plantaris. eMedicine. July 2008; Accessed 4/29/2011.
  2. Palmoplantar keratoderma. DermNet. November 18, 2014; Accessed 4/29/2011.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Palmoplantar keratoderma. Click on the link to go to to read descriptions of these studies.
Other Names for this Disease
  • Keratoderma, Palmoplantar
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.