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Diseases

Genetic and Rare Diseases Information Center (GARD)

Sclerosing mesenteritis


Other Names for this Disease
  • Retractile mesenteritis
  • Liposclerotic mesenteritis
  • Mesenteric lipogranuloma
  • Mesenteric fibromatosis
  • Mesenteric panniculitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might sclerosing mesenteritis be treated?

Treatment for sclerosing mesenteritis is most often based on the stage of the disease.

  • In the early stage when fat necrosis predominates, many physicians tend not to treat because the disease process may regress spontaneously.[1][2]
  • When chronic inflammation becomes a prominent feature but fibrosis is not yet fully developed, medical treatment with corticosteroids, colchicine, immunosuppressants, or orally administered progesterone may be beneficial in the prevention of disease progression.[1][3] These medications are only given for a short period since they can cause serious side effects. Some studies have shown that patients with sclerosing mesenteritis may benefit from a drug combination of tamoxifen and prednisone.[2][3]
  • When fibrosis becomes extensive, especially when the disease presents as a large fibrotic mass with bowel obstruction, surgical interventions may be necessary.[1][2][3]
Last updated: 10/1/2015

References
  1. Sclerosing Mesenteritis. The Doctor's Doctor Web site. 2002; http://www.thedoctorsdoctor.com/diseases/sclerosing_mesenteritis.htm. Accessed 10/1/2015.
  2. Ehrenpreis ED, Deepak P. Sclerosing mesenteritis. National Organization for Rare Disorders (NORD). 2011; http://rarediseases.org/rare-diseases/sclerosing-mesenteritis/. Accessed 10/1/2015.
  3. Sclerosing mesenteritis. MayoClinic.org. March 22, 2014; http://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/basics/definition/con-20037148. Accessed 10/1/2015.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information
Other Names for this Disease
  • Retractile mesenteritis
  • Liposclerotic mesenteritis
  • Mesenteric lipogranuloma
  • Mesenteric fibromatosis
  • Mesenteric panniculitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.