Other Names for this Disease
- Idiopathic sclerosing mesenteritis
- Isolated mesenteric lipodystrophy
- Lipomatous mesenteritis
- Liposclerotic mesenteritis
- Mesenteric fibromatosis
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Your QuestionI had surgery 5 years ago to remove sclerosing mesenteritis. Can this come back?
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Sclerosing mesenteritis is one of many terms used to describe a spectrum of chronic inflammatory diseases affecting the small bowel mesentery, the membrane that anchors the small intestine to the back of the abdominal wall. The cause of this condition is unknown. The most common symptom is abdominal pain or a palpable abdominal mass. Click on the highlighted text to view an illustration of the small intestine.
Last updated: 10/1/2015
Treatment for sclerosing mesenteritis is most often based on the stage of the disease.
- In the early stage when fat necrosis predominates, many physicians tend not to treat because the disease process may regress spontaneously.
- When chronic inflammation becomes a prominent feature but fibrosis is not yet fully developed, medical treatment with corticosteroids, colchicine, immunosuppressants, or orally administered progesterone may be beneficial in the prevention of disease progression. These medications are only given for a short period since they can cause serious side effects. Some studies have shown that patients with sclerosing mesenteritis may benefit from a drug combination of tamoxifen and prednisone.
- When fibrosis becomes extensive, especially when the disease presents as a large fibrotic mass with bowel obstruction, surgical interventions may be necessary.
Last updated: 10/1/2015
Although the results of surgical removal of benign cysts and solid tumors of the mesentery are very favorable, local recurrence has been reported.
Last updated: 7/21/2009
- Sclerosing mesenteritis. MayoClinic.org. March 22, 2014; http://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/basics/definition/con-20037148. Accessed 10/1/2015.
- S Akram, DS Pardi, JA Schaffner, TC Smyrk. Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol. 2007 May; 5(5):589-96. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=17478346%5Buid%5D. Accessed 10/1/2015.
- Townsend: Sabiston Textbook of Surgery, 17th ed.. Saunders, An Imprint of Elsevier ; 2004;
- Sclerosing Mesenteritis. The Doctor's Doctor Web site. 2002; http://www.thedoctorsdoctor.com/diseases/sclerosing_mesenteritis.htm. Accessed 10/1/2015.
- Ehrenpreis ED, Deepak P. Sclerosing mesenteritis. National Organization for Rare Disorders (NORD). 2011; http://rarediseases.org/rare-diseases/sclerosing-mesenteritis/. Accessed 10/1/2015.
- Seymour NE. Mesenteric Tumors: Follow-up. eMedicine. 2009; http://emedicine.medscape.com/article/191675-followup. Accessed 7/21/2009.