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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lafora disease


Other Names for this Disease
  • Lafora body disorder
  • Epilepsy progressive myoclonic 2
  • EPM2
  • Myoclonic epilepsy of Lafora
  • MELF
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Lafora disease be treated?

Unfortunately, there is currently no cure for Lafora disease or way to slow the progression of the condition. Treatment is based on the signs and symptoms present in each person. For example, certain medications may be recommended to managed generalized seizures. In the advanced stages of the condition, a gastrostomy tube may be placed for feeding. Drugs that are known to worsen myoclonus (i.e. phenytoin) are generally avoided.[1][2]

GeneReview's Web site offers more specific information regarding the treatment and management of Lafora disease. Please click on the link to access this resource.
Last updated: 9/28/2015

References
  1. Anna C Jansen, MD, PhD and Eva Andermann, MD, PhD, FCCMG. Progressive Myoclonus Epilepsy, Lafora Type. GeneReviews. January 2015; http://www.ncbi.nlm.nih.gov/books/NBK1389/#lafora.Clinical_Description.
  2. Monaghan TS, Delanty N. Lafora disease: epidemiology, pathophysiology and management. CNS Drugs. July 2010; 24(7):549-561.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Lafora disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Lafora body disorder
  • Epilepsy progressive myoclonic 2
  • EPM2
  • Myoclonic epilepsy of Lafora
  • MELF
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.