Other Names for this Disease
- Felty syndrome
- Rheumatoid arthritis, splenomegaly and neutropenia
- Familial Felty's syndrome
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rheumatoid arthritis (RA), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. Although some individuals with Felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. Symptoms of Felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), Sjögren syndrome, vasculitis, lower-extremity ulcers, and other findings. The exact cause is unknown, but several risk factors have been proposed, including autoimmunity. A few familial cases of the condition have been reported. Treatment typically focuses on controlling the underlying RA; immunosuppressive therapy for RA may improve neutropenia and splenomegaly.Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions:
Last updated: 2/21/2016
- Felty Syndrome. National Organization for Rare Disorders (NORD). 2006; http://rarediseases.org/rare-diseases/felty-syndrome/.
- Richard M Keating. Felty syndrome. Medscape Reference. February 2014; http://emedicine.medscape.com/article/329734-overview.
- Runge LA, Davey FR, Goldberg J, Boyd PR. The inheritance of Felty's syndrome in a family with several affected members. Journal of Rheumatology. February 1986; 13(1):39-42. http://www.ncbi.nlm.nih.gov/pubmed/3701742.
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- PubMed is a searchable database of medical literature and lists journal articles that discuss Felty's syndrome. Click on the link to view a sample search on this topic.