Other Names for this Disease
- Felty syndrome
- Rheumatoid arthritis, splenomegaly and neutropenia
- Familial Felty's syndrome
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The exact cause of Felty's syndrome is unknown, although several causes and risk factors have been proposed. Some experts believe it may be an autoimmune disorder, and that it may sometimes be inherited in an autosomal dominant manner. Other proposed risk factors have included:
- RF (rheumatoid factor) positivity - being positive for a test used to help diagnose rheumatoid arthritis
- Long-term rheumatoid arthritis
- Aggressive and erosive synovitis (inflammation of the tissue that lines the joints)
- HLA-DR4 positivity (having a specific gene for the immune system that is associated with RA) and DR4 homozygosity (having 2 identical copies of this gene)
- Extra-articular RA manifestations (symptoms that are not joint-related)
Last updated: 2/21/2016
- Felty Syndrome. National Organization for Rare Disorders (NORD). 2006; http://rarediseases.org/rare-diseases/felty-syndrome/.
- Richard M Keating. Felty syndrome. Medscape Reference. February 2014; http://emedicine.medscape.com/article/329734-overview.