Other Names for this Disease
- Mediastinal fibrosis
- Idiopathic mediastinal fibrosis
- Sclerosing mediastinitis
- IgG4-related mediastinitis
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 For example, some affected people may develop blocked airways that can interfere with lung function. Others may have compressed blood vessels which can slow or prevent blood flow to and from the heart. The exact cause of fibrosing mediastinitis is not fully understood, but it is not inherited. Many cases are linked to a specific type of fungal infection called histoplasmosis. Treatment depends on which structures of the mediastinum are affected, the severity of the scarring and, in some cases, the cause of the condition.Fibrosing mediastinitis is a condition that affects the area between the lungs (mediastinum) which contains the heart, large blood vessels, windpipe (trachea), esophagus, and lymph nodes. People with fibrosing mediastinitis have varying amounts of scar tissue in the mediastinum which may cause problems for the organs located there.
Last updated: 11/5/2014
- Histoplasmosis. MedlinePlus. October, 2012; http://www.nlm.nih.gov/medlineplus/ency/article/001082.htm. Accessed 11/3/2014.
- Rossi S, McAdams H, Rosado-de-Christenson M, Franks T, Galvin J. Fibrosing Mediastinitis. Radiographics. 2001; 21(3):737-757. Accessed 11/5/2014.
- L. Joseph Wheat, Alison G. Freifeld, Martin B. Kleiman, John W. Baddley, David S. McKinsey, James E. Loyd. Clinical Practice Guidelines for the Management of Patients with Histoplasmosis: 2007 Update by the Infectious Diseases Society of America. Clinical Infectious Disease. October, 2007; 45:807-825. http://www.idsociety.org/uploadedFiles/IDSA/Guidelines-Patient_Care/PDF_Library/Histoplasmosis.pdf#search=%22Mediastinal fibrosis%22. Accessed 11/3/2014.
- Steven E Weinberger, MD. Fibrosing Mediastinitis. UpToDate. Aug 06, 2013; http://www.uptodate.com/contents/fibrosing-mediastinitis. Accessed 11/5/2014.
- MedlinePlus provides more information on mediastinitis and histoplasmosis. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions. To view the information pages click on the links above.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Fibrosing mediastinitis. Click on the link to view a sample search on this topic.
- Peebles RS, Carpenter CT, Dupont WD, Loyd JE. Medistinal fibrosis is associated with human leukocyte antigen-A2. CHEST. 2000;112(2):482-485.