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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Tumor necrosis factor receptor-associated periodic syndrome


Other Names for this Disease
  • Familial Hibernian fever
  • FHF
  • FPF
  • Hibernian fever, familial
  • Periodic fever, familial, autosomal dominant
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Treatment

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How might tumor necrosis factor receptor-associated periodic syndrome (TRAPS) be treated?

While there is no proven treatment for TRAPS, non steroidal anti-inflammatory drugs (NSAIDS) may be used to relieve symptoms of fever, and corticosteroids may be used to reduce severity of symptoms in most people. However, these medications typically don't decrease the frequency of attacks. Etanercept, a TNF inhibitor, has been shown to be effective but its efficacy tends to wane over time. Standard doses of etanercept twice a week have been shown to decrease the frequency, duration, and severity of attacks in some people and it may also reverse or slow the progression of amyloidosis. More studies are needed to evaluate this medication for TRAPS.[1][2]

Additional information about the treatment of TRAPS can be viewed on Medscape's Web site.
Last updated: 6/25/2015

References
  1. Marco Gattorno. Tumor necrosis factor receptor 1 associated periodic syndrome. Orphanet. September, 2014; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=32960.
  2. Shinawi M. Hereditary Periodic Fever Syndromes. Medscape. January 11, 2013; http://emedicine.medscape.com/article/952254-overview#a4.


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Other Names for this Disease
  • Familial Hibernian fever
  • FHF
  • FPF
  • Hibernian fever, familial
  • Periodic fever, familial, autosomal dominant
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.