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Diseases

Genetic and Rare Diseases Information Center (GARD)

Moebius syndrome


Other Names for this Disease
  • Mobius syndrome
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • Moebius sequence
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Your Question

What are the chances of my 2nd child getting Moebius syndrome?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is Moebius syndrome inherited?

Most cases of Moebius syndrome are not inherited and occur as isolated cases in individuals with no history of the condition in their family (sporadically). A small percentage of cases of Moebius syndrome have been familial (occurring in more than one individual in a family), but there has not been a consistent pattern of inheritance among all affected families.[1][2] In some families the pattern has been suggestive of autosomal dominant inheritance, while in other families it has been suggestive of autosomal recessive or X-linked recessive inheritance.[2]
Last updated: 8/14/2014

What are the chances of having a second child with Moebius syndrome?

Most cases of Moebius syndrome are isolated, occurring sporadically in only one individual in a family. Although a few familial cases have been reported, no specific genetic cause of the condition has been identified and the manner in which the condition may be inherited is unclear. While the exact recurrence risk for Moebius syndrome in a family with one affected individual is not known, it has been estimated to be about 2% (1 in 50).[2]

Individuals who are interested in learning more about their individual risk to have a child affected with Moebius syndrome may consider speaking with a genetics professional.
Last updated: 7/15/2013

How can I find a genetics professional in my area?

To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by GeneTests, the American College of Medical Genetics, and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.
Last updated: 7/15/2016

References
Other Names for this Disease
  • Mobius syndrome
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • Moebius sequence
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.