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Diseases

Genetic and Rare Diseases Information Center (GARD)

Moebius syndrome


Other Names for this Disease
  • Mobius syndrome
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • Moebius sequence
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Moebius syndrome is a rare neurological condition that primarily affects the muscles that control facial expression and eye movement. Signs and symptoms of the condition may include weakness or paralysis of the facial muscles; feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; eye sensitivity; high or cleft palate; hearing problems; dental abnormalities; bone abnormalities in the hands and feet; and/or speech difficulties. Affected children often experience delayed development of motor skills (such as crawling and walking), although most eventually acquire these skills.[1][2] Moebius syndrome is caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movement and facial expression. Other cranial nerves may also be affected. There is no cure for Moebius syndrome, but proper care and treatment give many individuals a normal life expectancy.[2]
Last updated: 3/3/2016

References

  1. Moebius syndrome. Genetics Home Reference. July 2010; http://ghr.nlm.nih.gov/condition/moebius-syndrome.
  2. NINDS Moebius Syndrome Information Page. National Institute of Neurological Disorders and Stroke, National Institutes of Health. June 23, 2011; http://www.ninds.nih.gov/disorders/mobius/moebius.htm.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Moebius syndrome. This website is maintained by the National Library of Medicine.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • A Positive Exposure program called FRAME has an educational film about Moebius syndrome that was created to change how medical information is presented to healthcare professionals. FRAME stands for Faces Redefining the Art of Medical Education. Positive Exposure is an organization that uses photography, film, and narrative to transform public perceptions of people living with genetic, physical, intellectual, and behavioral differences.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Moebius syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Mobius syndrome
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • Moebius sequence
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.