Limb-girdle muscular dystrophy, type 2B
Other Names for this Disease
- Muscular dystrophy, limb-girdle, type 3
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limb-girdle muscular dystrophy, a group of disorders that affect the voluntary muscles of the hips and shoulders. LGMD2B is characterized by early weakness and wasting (atrophy) of the pelvic and shoulder girdle muscles in adolescence or young adulthood. The age of onset typically ranges from 15 to 35 years, and legs are usually affected first. Symptoms include the inability to tiptoe and difficulty walking and running. Cardiac (heart) and respiratory involvement is uncommon. It is usually slowly progressive, with need of a wheelchair 10 to 20 years after onset. LGMD2B is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner. There is no specific treatment. Management is tailored to each person and may include physical therapy and stretching exercises; use of aids for mobility; and surgery as needed for orthopedic complications.Limb-girdle muscular dystrophy, type 2B (LGMD2B) is one of many forms of
Last updated: 3/21/2016
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- Genetics Home Reference (GHR) contains information on Limb-girdle muscular dystrophy, type 2B. This website is maintained by the National Library of Medicine.
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