Balkan endemic nephropathy
Other Names for this Disease
- Aristolochic acid nephropathy
- Danubian endemic familial nephropathy
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kidney failure. Many people with this condition also develop a type of bladder cancer known as upper urothelial carcinoma (UUC) or transitional cell carcinoma. Balkan endemic nephropathy is caused by eating bread that is contaminated with a toxin called aristolochic acid, which comes from a plant called Aristolochia. Balkan endemic nephropathy can occur in multiple family members, but it is not an inherited condition.Balkan endemic nephropathy is a kidney disease that affects people living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia. Affected individuals develop kidney damage that progresses to
Last updated: 4/4/2011
- Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, et al. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA. 2007 Jul 17; 104(29):12129-34. http://www.pnas.org/content/104/29/12129.long. Accessed 4/4/2011.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Balkan endemic nephropathy. Click on the link to view a sample search on this topic.
- Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, et al. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA. 2007 Jul 17;104(29):12129-34. Available at: http:/
/ www.pnas.org/ content/ 104/ 29/ 12129.long.