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Diseases

Genetic and Rare Diseases Information Center (GARD)

Systemic mastocytosis


Other Names for this Disease
  • SMCD
  • Systemic mast cell disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might systemic mastocytosis be treated?

Treatment for systemic mastocytosis (SM) is based on the signs and symptoms present in each person. For example, the following medications may used to treat various symptoms associated with SM:[1][2]
  • Antihistamines to treat or prevent skin and gastrointestinal symptoms
  • Proton pump inhibitors to treat increased stomach acid
  • Epinephrine to treat anaphylaxis
  • Steroids to treat malabsorption (impaired ability to take in nutrients)
  • Mast-cell stabilizers such as ketotifen to treat some of the skin symptoms
  • Cromolyn sodium to treat gastrointestinal symptoms, bone pain, headaches, and some of the skin manifestations

If systemic mastocytosis is cancerous (mast cell leukemia) or associated with a blood disorder, steroids and/or chemotherapy may be necessary.[3]

More specific information about treatment options can be accessed through the Treatment and Medication sections of the Medscape Reference Web site.
Last updated: 6/17/2015

References
  1. Koyamangalath Krishnan, MD, FRCP, FACP. Systemic Mastocytosis. Medscape Reference. March 2015; http://emedicine.medscape.com/article/203948-overview#showall.
  2. Mariana C Castells, MD, PhD; Cem Akin, MD, PhD. Treatment and prognosis of systemic mastocytosis. UpToDate. April 2015; Accessed 6/17/2015.
  3. Mastocytosis. National Institute of Allergy and Infectious Diseases (NIAID). October 2013; http://www.niaid.nih.gov/topics/mastocytosis/Pages/Treatment.aspx.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Systemic mastocytosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • SMCD
  • Systemic mast cell disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.