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Diseases

Genetic and Rare Diseases Information Center (GARD)

Systemic mastocytosis


Other Names for this Disease
  • SMCD
  • Systemic mast cell disease
Related Diseases
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Your Question

My mother is suffering from systemic mastocytosis. What types of treatment are available for this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might systemic mastocytosis be treated?

Treatment for systemic mastocytosis (SM) is based on the signs and symptoms present in each person. For example, the following medications may used to treat various symptoms associated with SM:[1][2]
  • Antihistamines to treat or prevent skin and gastrointestinal symptoms
  • Proton pump inhibitors to treat increased stomach acid
  • Epinephrine to treat anaphylaxis
  • Steroids to treat malabsorption (impaired ability to take in nutrients)
  • Mast-cell stabilizers such as ketotifen to treat some of the skin symptoms
  • Cromolyn sodium to treat gastrointestinal symptoms, bone pain, headaches, and some of the skin manifestations

If systemic mastocytosis is cancerous (mast cell leukemia) or associated with a blood disorder, steroids and/or chemotherapy may be necessary.[3]

More specific information about treatment options can be accessed through the Treatment and Medication sections of the Medscape Reference Web site.
Last updated: 6/17/2015

References
Other Names for this Disease
  • SMCD
  • Systemic mast cell disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.