Other Names for this Disease
- Idiopathic myelofibrosis
- Myeloid metaplasia
- Agnogenic myeloid metaplasia
- Primary myelofibrosis
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 When the bone marrow is scarred, it cannot make enough blood cells. This leads to anemia, weakness, fatigue, and often, swelling of the liver and spleen. The condition occurs when blood stem cells develop somatic mutations in the JAK2, MPL, CALR, and TET2 genes. Other genes may also be involved. The condition is generally not inherited. Although myelofibrosis can occur at any age, it typically develops after the age of 50. In most cases, myelofibrosis gets progressively worse. Treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue.
Last updated: 6/22/2016
- Chen YB. Myelofibrosis. MedlinePlus. May 29, 2014; http://www.nlm.nih.gov/medlineplus/ency/article/000531.htm.
- Myelofibrosis. MayoClinic.com. August 1, 2014; http://www.mayoclinic.com/print/myelofibrosis/DS00886/DSECTION=all&METHOD=print.
- Primary myelofibrosis. Genetics Home Reference (GHR). September 2014; https://ghr.nlm.nih.gov/condition/primary-myelofibrosis.
- Genetics Home Reference (GHR) contains information on Myelofibrosis. This website is maintained by the National Library of Medicine.
- MayoClinic.com offers additional information about myelofibrosis. Click on the above link to access this information.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The MPN Education Foundation provides information on Myelofibrosis.
- The Leukemia & Lymphoma Society has an article on idiopathic myelofibrosis. Click on Leukemia & Lymphoma Society to view the article.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Myelofibrosis. Click on the link to view a sample search on this topic.