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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Intraocular melanoma


Other Names for this Disease
  • Choroidal melanoma
  • Iris melanoma
  • Melanoma of the Uvea
  • Uveal melanoma
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Overview

Intraocular melanoma is a cancer of the pigment-producing cells (melanocytes) in the middle layer of the eye, called the uveal tract.[1]  The uveal tract has 3 main parts: (1) the choroid (the tissue layer filled with blood vessels); (2) the ciliary body (the ring of muscle tissue that changes the size of the pupil and the shape of the lens); and (3) the iris (the colored part of the eye). Most cases (90%) of intraocular melanoma develop in the choroid, called choroidal melanoma; the ciliary body is less commonly a site of origin, and the iris is the least common.  Each manifests with different clinical features and symptoms. [2] Treatment depends on the site of origin (choroid, ciliary body, or iris), size and location of the tumor, the age of the individual, and other factors.[1] 
Last updated: 11/29/2010

References

  1. Intraocular (Eye) Melanoma Treatment (PDQ). National Cancer Institute. 06/15/2010; http://www.cancer.gov/cancertopics/pdq/treatment/intraocularmelanoma/Patient/page5. Accessed 11/29/2010.
  2. Shields, Carol, M.D., Shields, Jerry, M.D.. Ocular melanoma: relatively rare but requiring respect. Clinics in Dermatology. 2009;
  3. About Ocular Melanoma. Ocular Melanoma Foundation. http://www.ocularmelanoma.org/about-om. Accessed 11/29/2010.
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Intraocular melanoma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Choroidal melanoma
  • Iris melanoma
  • Melanoma of the Uvea
  • Uveal melanoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.