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Diseases

Genetic and Rare Diseases Information Center (GARD)

Intraocular melanoma


Other Names for this Disease
  • Melanoma of the Uvea
  • Uveal melanoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Intraocular melanoma is a cancer of the pigment-producing cells (melanocytes) in the middle layer of the eye, called the uveal tract.[1]  The uveal tract has 3 main parts: (1) the choroid (the tissue layer filled with blood vessels); (2) the ciliary body (the ring of muscle tissue that changes the size of the pupil and the shape of the lens); and (3) the iris (the colored part of the eye). Most cases (90%) of intraocular melanoma develop in the choroid, called choroidal melanoma; the ciliary body is less commonly a site of origin, and the iris is the least common.  Each manifests with different clinical features and symptoms. [2] Treatment depends on the site of origin (choroid, ciliary body, or iris), size and location of the tumor, the age of the individual, and other factors.[1] 
Last updated: 11/29/2010

References

  1. Intraocular (Eye) Melanoma Treatment (PDQ). National Cancer Institute. 06/15/2010; http://www.cancer.gov/cancertopics/pdq/treatment/intraocularmelanoma/Patient/page5. Accessed 11/29/2010.
  2. Shields, Carol, M.D., Shields, Jerry, M.D.. Ocular melanoma: relatively rare but requiring respect. Clinics in Dermatology. 2009;
  3. About Ocular Melanoma. Ocular Melanoma Foundation. http://www.ocularmelanoma.org/about-om. Accessed 11/29/2010.
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Intraocular melanoma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Melanoma of the Uvea
  • Uveal melanoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.