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Diseases

Genetic and Rare Diseases Information Center (GARD)

Autoimmune progesterone dermatitis


Other Names for this Disease
  • APD
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Treatment

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How might autoimmune progesterone dermatitis be treated?

The treatment or control of symptoms of autoimmune progesterone dermatitis (APD) varies. Mild cases might be successfully managed with use of antihistamines and/or corticosteroids.

Most methods of treatment focus on temporarily suppressing ovulation. This might be achieved through varying medications including: conjugated estrogenethinyl estradioltamoxifen, and danazolGonadotropin releasing hormone agonists have additionally had reported success in the literature; however as these medications can prompt symptoms of menopause, they might not be recommended for pre-menopausal patients. Progesterone desensitization, in which increasing doses of progesterone are administered via vaginal suppository,  has been reported as a successful treatment in one case in the literature. 

For severe cases in which the above treatment options are not successful, surgical removal of ovaries or oophorectomy is curative.[1][2]

Last updated: 3/9/2016

References
  1. Autoimmune progesterone dermatitis. DermNet NZ. December 2013; http://dermnetnz.org/reactions/progesterone-dermatitis.html.
  2. Tegan Nguyen, A. Razzaque Ahmed. Autoimmune progesterone dermatitis: Update and insights. Autoimmunity Reviews. 2/2016; 15(2):191-197. http://www.ncbi.nlm.nih.gov/pubmed/?term=26554933.


Other Names for this Disease
  • APD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.