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Diseases

Genetic and Rare Diseases Information Center (GARD)

Membranous nephropathy


Other Names for this Disease
  • Idiopathic membranous nephropathy
  • MGN
  • Membranous glomerulonephritis
  • Membranous GN
  • Glomerulonephritis, membranous
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Overview

Membranous nephropathy is a kidney disease characterized by inflammation of the structures inside the kidney that help filter wastes and fluids.[1] When the glomerular basement membrane becomes thickened, it does not work normally, allowing large amounts of protein to be lost in the urine. Symptoms develop gradually and may include swelling, fatigue, weight gain, and high blood pressure. In many cases, the underlying cause of membranous nephropathy is not known. Some cases are associated with other conditions (lupus), infections (hepatitis B and C), cancer or as a side effect of certain medications.[1][2] The goal of treatment is to reduce symptoms and slow the progression of the disease.[1] 
Last updated: 9/2/2014

References

  1. Silberberg C. Membranous nephropathy. MedlinePlus. September 8, 2013; http://www.nlm.nih.gov/medlineplus/ency/article/000472.htm. Accessed 9/2/2014.
  2. Membranous Nephropathy (MN). Nephrotic Syndrome Study Network (NEPTUNE). http://www.rarediseasesnetwork.org/NEPTUNE/patients/learnmore/MN/. Accessed 9/2/2014.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for health care professionals provides information on Membranous nephropathy.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
Other Names for this Disease
  • Idiopathic membranous nephropathy
  • MGN
  • Membranous glomerulonephritis
  • Membranous GN
  • Glomerulonephritis, membranous
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.