Other Names for this Disease
- Glutamate decarboxylase deficiency
- Pyridoxine dependency
- Pyridoxine dependency with seizures
- Pyridoxine-responsive seizures
- Vitamin B6-dependent seizures
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Anticonvulsant drugs, which are usually given to control seizures, are ineffective in people with pyridoxine-dependent epilepsy. Instead, people with this type of seizure are medically treated with large daily doses of pyridoxine (a type of vitamin B6 found in food). Recent studies have focused on using a lysine-restricted diet in addition to pyridoxine. Preliminary results suggest that this treatment has the potential to help control seizures and improve developmental outcomes in children with pyridoxine-dependent epilepsy.
Last updated: 7/23/2013
- Pyridoxine-dependent epilepsy. Genetics Home Reference (GHR). 2013; http://ghr.nlm.nih.gov/condition=pyridoxinedependentepilepsy. Accessed 7/23/2013.
- Gospe SM. Pyridoxine-Dependent Seizures. GeneReviews. 2012; http://www.ncbi.nlm.nih.gov/books/NBK1486/. Accessed 7/23/2013.
- van Karnebeek CD et al. Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. Mol Genet Metab. 2012 Nov;107(3):335-44. .
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.
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