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Diseases

Genetic and Rare Diseases Information Center (GARD)

Childhood brain stem glioma


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Overview

Childhood brain stem glioma is a rare condition in which abnormal cells develop in the tissues of the brain stem (the part of the brain connected to the spinal cord). The condition can be benign (noncancerous) or malignant (cancerous). The severity of the condition and the associated signs and symptoms vary based on the size and location of the tumor and how quickly the tumor is growing. Common features include difficulty walking; loss of the ability to move one side of the body or face; vision or hearing problems; headaches (particularly in the morning); nausea and vomiting; unusual sleepiness; and behavioral changes. In most cases, the underlying cause of childhood brain stem glioma is unknown. Certain genetic conditions, such as neurofibromatosis type I, are associated with an increased risk of childhood brainstem glioma. Treatment varies but may include surgery, radiation therapy, chemotherapy, cerebrospinal fluid diversion, observation, and targeted therapy.[1][2][3]
Last updated: 5/31/2016

References

  1. Childhood Brain Stem Glioma Treatment (PDQ®)–Patient Version. National Cancer Institute. May 2016; http://www.cancer.gov/types/brain/patient/child-glioma-treatment-pdq#section/_76.
  2. Childhood Brain Stem Glioma Treatment (PDQ®)–Health Professional Version. National Cancer Institute. May 2016; http://www.cancer.gov/types/brain/hp/child-glioma-treatment-pdq.
  3. Joseph C Landolfi, DO. Brainstem Gliomas. Medscape Reference. March 2014; http://emedicine.medscape.com/article/1156030-overview.
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
  • The Cleveland Clinic Web site has an information page on Childhood brain stem glioma. Click on the Cleveland Clinic link to view this page.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Childhood brain stem glioma. Click on the link to view a sample search on this topic.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.