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Diseases

Genetic and Rare Diseases Information Center (GARD)

Childhood hepatocellular carcinoma


Other Names for this Disease
  • Childhood Carcinoma of Liver Cell
  • Childhood Hepatoma
  • Childhood Liver Cell Carcinoma
  • Pediatric Carcinoma of Liver Cell
  • Pediatric Hepatocellular Carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Childhood hepatocellular carcinoma (childhood HCC) is a rare type of malignant (cancerous) tumor that forms in the cells and tissues of the liver.[1] Childhood HCC is usually found in older children and adolescents (10-14 years), but has been found in children younger than 5.[2] Symptoms may include a mass in the abdomen, a swollen and painful abdomen, weight loss, poor appetite, yellowing of the skin and eyes (jaundice), vomiting, fever, itchy skin, and a decreased number of red blood cells (anemia).[3][1] The cause of childhood HCC is not well understood; however, underlying disorders that cause liver dysfunction (ex. hepatitis B) and congenital or genetic disorders that affect the liver (ex. tyrosinemia type 1) may increase the risk for childhood HCC to occur.[1][2] Treatment options vary depending on a variety of factors including the stage of the cancer and may include surgery to remove the tumor and chemotherapy.[1]
Last updated: 7/14/2016

References

  1. Pr Piotr CZAUDERNA. Pediatric hepatocellular carcinoma. Orphanet. November 2014; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=33402.
  2. Deirdre Kelly, Khalid Sharif, Rachel M. Brown, Bruce Morland. Hepatocellular Carcinoma in Children. Clin Liver Dis. May 2015; 19(2):433-447. http://www.ncbi.nlm.nih.gov/pubmed/25921672.
  3. Paulette Mehta. Pediatric Hepatocellular Carcinoma. Medscape. November 5, 2015; http://emedicine.medscape.com/article/986988.
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Basic Information

  • Children's Hospital Boston Web site has an information page on hepatocellular carcinoma, childhood. Click on the link above to view this information page.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Childhood hepatocellular carcinoma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Childhood Carcinoma of Liver Cell
  • Childhood Hepatoma
  • Childhood Liver Cell Carcinoma
  • Pediatric Carcinoma of Liver Cell
  • Pediatric Hepatocellular Carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.