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Diseases

Genetic and Rare Diseases Information Center (GARD)

Fibrolamellar carcinoma


Other Names for this Disease
  • Fibrolamellar hepatocellular carcinoma
  • Eosinophilic hepatocellular carcinoma with lamellar fibrosis
  • Polygonal cell hepatocellular carcinoma with fibrous stroma
  • Hepatocellular carcinoma with increased stromal fibrosis
  • Eosinophilic glassy cell hepatoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Fibrolamellar carcinoma (FLC) is a rare form of liver cancer which is generally diagnosed in adolescents and young adults (before age 40). Many people with early FLC have no signs or symptoms of the condition. When present, symptoms are often nonspecific (i.e. abdominal pain, weight loss, malaise) and blamed on other, more common conditions. The exact underlying cause of FLC is poorly understood. Unlike other forms of liver cancer, FLC typically occurs in the absence of underlying liver inflammation or scarring; thus, specific risk factors for this condition remain unidentified. FLC is typically treated with surgical resection.[1][2][3]
Last updated: 4/23/2015

References

  1. Michael A Choti, MD, MBA, FACS. Fibrolamellar Carcinoma. Medscape Reference. August 2015; http://emedicine.medscape.com/article/278354-overview.
  2. Lim II, Farber BA, LaQuaglia MP. Advances in fibrolamellar hepatocellular carcinoma: a review. Eur J Pediatr Surg. December 2014; 24(6):461-466.
  3. Arief Suriawinata, MD. Pathology of malignant liver tumors. UpToDate. November 2014; Accessed 4/22/2015.
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In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fibrolamellar carcinoma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Fibrolamellar hepatocellular carcinoma
  • Eosinophilic hepatocellular carcinoma with lamellar fibrosis
  • Polygonal cell hepatocellular carcinoma with fibrous stroma
  • Hepatocellular carcinoma with increased stromal fibrosis
  • Eosinophilic glassy cell hepatoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.