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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pseudoangiomatous stromal hyperplasia

*

* Not a rare disease

Other Names for this Disease
  • PASH
  • Mammary pseudoangiomatous stromal hyperplasia
  • Pseudoangiomatous stromal hyperplasia of the breast
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Overview

Pseudoangiomatous stromal hyperplasia (PASH) is a type of non-cancerous breast lesion. It typically affects women in the reproductive age group.[1][2] Occasional cases have been described in men, postmenopausal women, adolescents, and children.[2] The size of the lesion varies, but small microscopic PASH is much more common than larger (tumorous) masses. Microscopic PASH is often an incidental finding in breast biopsies done for other non-cancerous or cancerous lesions. Tumorous PASH presents as a firm, painless breast mass or a dense region on a mammogram.[1][2][3] The underlying cause of PASH is unclear. There is some evidence in the literature to suggest that hormonal factors may play a role. While PASH itself is benign, it may mimic cancer (specifically angiosarcoma). For this reason, a biopsy may be recommended. Treatment may include observation or surgical excision.[2]  
Last updated: 7/14/2016

References

  1. Virk RK, Khan A. Pseudoangiomatous stromal hyperplasia: an overview. Arch Pathol Lab Med. 2010 Jul; 134(7):1070-4. https://www.ncbi.nlm.nih.gov/pubmed/20586640.
  2. Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, and Bumpers HL. Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Series of 24 Patients.. Breast J. 2012 May-Jun; 18(3):242-247. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658111/.
  3. Cyrlak D, Carpenter PM. Breast imaging case of the day: Pseudoangiomatous stromal hyperplasia. Radiographics. 1999; 19:1086-1088. http://pubs.rsna.org/doi/full/10.1148/radiographics.19.4.g99jl201086.
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Basic Information

  • The American Cancer Society provides information on benign (non-cancerous) breast conditions.  Click on the American Cancer Society link to view this information.

In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pseudoangiomatous stromal hyperplasia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • PASH
  • Mammary pseudoangiomatous stromal hyperplasia
  • Pseudoangiomatous stromal hyperplasia of the breast
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.