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primary ovarian insufficiency (POI). It happens when the body's immune system mistakenly attacks the ovaries causing inflammation, atrophy and fibrosis. These changes stop the ovaries from working normally. The main symptoms of autoimmune oophorotis are irregular or absent menstrual period (amenorrhea) and symptoms related to ovarian cysts such as abdominal cramping, bloating, nausea and vomiting. Autoimmune oophoritis may occur as part of autoimmune polyglandular syndrome type I and type II but has also been associated with lupus, pernicious anemia, myasthenia gravis and other autoimmune conditions. The underlying cause of autoimmune oophoritis is unknown. Diagnosis involves a special blood test which looks for anti-steroid or anti-ovarian antibodies, a pelvic ultrasound to look for enlarged cystic ovaries and tests to rule out other possible causes of POI. Management of autoimmune oophoritis involves emotional support, possible estrogen replacement therapy and management of other autoimmune conditions.Autoimmune oophoritis is a rare cause of
Last updated: 6/6/2016
- Nelson LM. Clinical features and diagnosis of autoimmune primary ovarian insufficiency (premature ovarian failure). UpToDate. September 21 2015; http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-autoimmune-primary-ovarian-insufficiency-premature-ovarian-failure.
- Jacob S and Koc M. Autoimmune oophoritis: a rarely encountered ovarian lesion. Indian J Pathol Microbiol. April-June 2015; 58(2):249-51. http://www.ncbi.nlm.nih.gov/pubmed/25885148.
- Welt CK. Autoimmune oophoritis in the adolescent. Ann N Y Acad Sci. 2008; 1135:118-22. http://www.ncbi.nlm.nih.gov/pubmed/18574216.
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- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Autoimmune oophoritis. Click on the link to view a sample search on this topic.