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Diseases

Genetic and Rare Diseases Information Center (GARD)

Melorheostosis


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Overview

Melorheostosis is a rare skeletal abnormality. It causes a lesion of bone to become overly thick and dense. The skin and soft tissues surrounding the bone lesion also harden. Melorheostosis tends to be limited to one extremity.[1] Melorheostosis can cause pain, limit range of movement (if a joint is involved), or stunt the growth of an affected extremity.[1]  Melorheostosis is thought to occur during fetal development, however signs and symptoms tend not to present until later childhood or early adulthood. Melorheostosis is a sporadic condition, and is not inherited.[1]
Last updated: 6/16/2015

References

  1. Gagliardi GG, Mahan KT. Melorheostosis: a literature review and case report with surgical considerations. J Foot Ankle Surg. 2010 Jan-Feb; 49(1):80-5. Accessed 6/16/2015.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Melorheostosis. Click on the link to view a sample search on this topic.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.