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Diseases

Genetic and Rare Diseases Information Center (GARD)

Melorheostosis


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Treatment

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How might melorheostosis be treated?

Data on treatment for melorheostosis is limited, however non-surgical and surgical approaches to manage pain has been described in single cases with some success:[1] Bisphosphonate therapy was successful in managing pain in a man with melorheostosis and elevated serum alkaline phosphatase. Nifedipine was used to treat a woman with melorheostosis and aching, burning pain deep in her upper left thigh. While the treatment was helpful in managing pain, the treatment was withdrawn due to unwanted side-effects. Pain was addressed in two additional cases with cortical fenestration, or surgically cutting an opening in large bone lesions.[1]

The limited movement in affected joints (contracture) can be difficult to treat and may be permanent. Tailored surgery to address the bone deformity, hardened surrounding soft tissues, and joint contractures have been preformed with variable results. Symptoms can recur following surgery. Surgery  may also be an option for treatment of limb length discrepancy.[1]
Last updated: 6/17/2015

References
  1. Gagliardi GG, Mahan KT. Melorheostosis: a literature review and case report with surgical considerations. J Foot Ankle Surg. 2010 Jan-Feb; 49(1):80-5. Accessed 6/16/2015.


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Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.