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Congenital anosmia


Other Names for this Disease
  • ANIC
  • Isolated congenital anosmia
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Overview

Congenital anosmia is a very rare condition in which people are born with a lifelong inability to smell. It may occur as an isolated abnormality (no additional symptoms) or be associated with a specific genetic disorder (such as Kallmann syndrome and congenital insensitivity to pain). Scientists suspect that isolated congenital anosmia occurs due to abnormal development of the olfactory system (the sensory system used for sense of smell) prior to birth. This may include abnormalities of the nasal cavity, disruptions in the pathway that carries information from the nose to the brain, and/or malformations of the portion of the brain that processes sense of smell.[1] Unfortunately, there is currently no known cure or treatment for congenital anosmia.[2]
Last updated: 6/9/2015

References

  1. Karstensen HG, Tommerup N. Isolated and syndromic forms of congenital anosmia. Clin Genet. March 2012; 81(3):210-215.
  2. Donald Leopold, MD. Disorders of Taste and Smell. Medscape Reference. April 2014; http://emedicine.medscape.com/article/861242-overview#aw2aab6b5.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute on Deafness and Other Communication Disorders (NIDCD) conducts and supports biomedical and behavioral research and research training in the normal and disordered processes of hearing, balance, smell, taste, voice, speech, and language. Click on the link to view information on this topic. 

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Congenital anosmia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • ANIC
  • Isolated congenital anosmia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.