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Diseases

Genetic and Rare Diseases Information Center (GARD)

Geniospasm


Other Names for this Disease
  • Trembling chin
  • GSM 1
  • Hereditary chin tremor/myoclonus
  • Hereditary geniospasm
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Overview

Hereditary geniospasm is a movement disorder that causes episodes of involuntary tremors of the chin and lower lip. The episodes may last anywhere from a few seconds to hours and may occur spontaneously or be brought on by stress. The episodes usually first appear in infancy or childhood and tend to lessen in frequency with age. Hereditary geniospasm is believed to be inherited in an autosomal dominant pattern. Although the exact gene(s) that cause the condition are unknown, it has been suggested that mutations in a gene on chromosome 9 may be responsible in some families.[1][2]
Last updated: 6/5/2013

References

  1. Geniospasm 1. OMIM (Online Mendelian Inheritance in Man). June 30, 2004; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190100. Accessed 7/21/2009.
  2. Jarman PR, Wood NW, Davis MT, Davis PV, Bhatia KP, Marsden CD, Davis MB. Am. J. Hum. Genet. 1997; http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1715984&blobtype=pdf. Accessed 7/21/2009.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Geniospasm. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Trembling chin
  • GSM 1
  • Hereditary chin tremor/myoclonus
  • Hereditary geniospasm
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.