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Diseases

Genetic and Rare Diseases Information Center (GARD)

Melioidosis


Other Names for this Disease
  • Burkholderia pseudomallei infection
  • B pseudomallei infection
  • Whitmore disease
  • Nightcliff gardener's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water.[1] Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia.[2][3] The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia.[4] Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more.[4] Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected.[4] Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria.[2] Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence.[2]
Last updated: 1/13/2016

References

  1. Angus Chen. This Germ Can Live Decades In Distilled Water, Kill Humans In 48 Hours. National Public Radio. January 12, 2016; http://www.npr.org/sections/goatsandsoda/2016/01/11/462416728/this-germ-can-live-decades-in-distilled-water-kill-humans-in-48-hours.
  2. Melioidosis. CheckOrphan. http://www.checkorphan.org/diseases/meliodosis. Accessed 1/13/2016.
  3. Melioidosis. Virginia Department of Health. August, 2013; http://www.vdh.virginia.gov/Epidemiology/factsheets/pdf/Melioidosis.pdf.
  4. Melioidosis: Signs and Symptoms. Centers for Disease Control and Prevention. October 22, 2012; http://www.cdc.gov/melioidosis/signs-symptoms.html.
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In Depth Information

  • CheckOrphan has a webpage with information about symptoms, prevention, diagnosis, prognosis, treatment and more. 
  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Melioidosis. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Burkholderia pseudomallei infection
  • B pseudomallei infection
  • Whitmore disease
  • Nightcliff gardener's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.