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Diseases

Genetic and Rare Diseases Information Center (GARD)

Retroperitoneal fibrosis


Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
  • IgG4-related retroperitoneal fibrosis
  • Ormond disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Retroperitoneal fibrosis is a slowly progressive disorder in which the tubes that carry urine from the kidneys to the bladder (ureters) and other abdominal organs or vessels become blocked by a fibrous mass and inflammation in the back of the abdomen. The disorder may cause pain in the abdomen that worsens with time, pain or swelling of the legs, decreased urine output, and swelling of the scrotum in men.[1][2] Risk factors for retroperitoneal fibrosis include asbestos exposure, smoking, tumor, infection, trauma, radiotherapy, surgery, and use of certain drugs.[1][2][3][4]Treatment may include corticosteroids, tamoxifen, stents or surgery.[1] 
Last updated: 6/20/2016

References

  1. Sobol J. Retroperitoneal fibrosis. MedlinePlus. June 29, 2015; http://www.nlm.nih.gov/medlineplus/ency/article/000463.htm.
  2. Retroperitoneal fibrosis. Genetics Home Reference (GHR). July 2013; https://ghr.nlm.nih.gov/condition/retroperitoneal-fibrosis.
  3. Vaglio A, Salvarani C, Buzio C. Retroperitoneal fibrosis. Lancet. 2006 Jan 21; 367(9506):241-51. https://www.ncbi.nlm.nih.gov/pubmed/?term=16427494.
  4. Goldoni M, Bonini S, Urban ML, Palmisano A, De Palma G, Galletti E, Coggiola M, Buzio C, Mutti A, Vaglio A. Asbestos and smoking as risk factors for idiopathic retroperitoneal fibrosis: a case-control study. Ann Intern Med. 2014 Aug 5; 161(3):181-8. http://www.ncbi.nlm.nih.gov/pubmed/25089862.
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Basic Information

  • Genetics Home Reference contains information on Retroperitoneal fibrosis. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Retroperitoneal fibrosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
  • IgG4-related retroperitoneal fibrosis
  • Ormond disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.