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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Retroperitoneal fibrosis

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Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
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Treatment

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How might retroperitoneal fibrosis be treated?

Treatment of retroperitoneal fibrosis may include:[1][2]

Corticosteroids are tried first. Dosing will be prescribed on a case by case basis, but doses often vary between 30 and 60 mg per day. Corticosteroids are then tapered slowly. Some people with retroperitoneal fibrosis may continue on low dose maintenance therapy for up to 2 years.[3] If corticosteroid treatment doesn't work, a biopsy should be done to confirm the diagnosis.[1] Other medicines to suppress the immune system, such as mycophenolate mofetil, methotrexate, azathioprine, cyclophosphamide or tamoxifen can be prescribed alone or in combination with corticosteroids.[1] When medicine does not work, surgery and stents (draining tubes) are considered. Stents (drainage tubes) placed in the ureter or in the renal pelvis may provide short-term relief of the symptoms until the condition is surgically treated.[2] Surgery aims to remove the mass and/or free the ureters.

Last updated: 4/22/2015

References
  1. Vorvick LJ. Retroperitoneal fibrosis. MedlinePlus. March 17, 2011; http://www.nlm.nih.gov/medlineplus/ency/article/000463.htm. Accessed 10/15/2013.
  2. Vaglio A, Salvarani C, Buzio C. Retroperitoneal fibrosis. Lancet. 2006; http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=16427494%5Buid%5D. Accessed 10/15/2013.
  3. Tzou M, Gazeley DJ, Mason PJ. Retroperitoneal fibrosis. Vasc Med. 2014 Oct; 19(5):407-14. Accessed 4/22/2015.


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  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

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Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Retroperitoneal fibrosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.