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Diseases

Genetic and Rare Diseases Information Center (GARD)

Retroperitoneal fibrosis


Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
  • IgG4-related retroperitoneal fibrosis
  • Ormond disease
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Cause

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What causes retroperitoneal fibrosis?

The cause of retroperitoneal fibrosis is unknown in many cases (idiopathic).[1][2] Occasionally, it may occur with autoimmune disorders and some researchers suggest that the immune system may be involved.[2] Some cases occur in association with other factors, including:[1][2][3][4]
  • Asbestos exposure
  • Smoking
  • Neoplasms (tumor)
  • Infections
  • Trauma
  • Radiotherapy
  • Surgery
  • Use of certain drugs (including those that contain methysergide, a medication sometimes used to treat migraines)
Last updated: 6/21/2016

References
  1. Sobol J. Retroperitoneal fibrosis. MedlinePlus. June 29, 2015; http://www.nlm.nih.gov/medlineplus/ency/article/000463.htm.
  2. Retroperitoneal fibrosis. Genetics Home Reference (GHR). July 2013; https://ghr.nlm.nih.gov/condition/retroperitoneal-fibrosis.
  3. Vaglio A, Salvarani C, Buzio C. Retroperitoneal fibrosis. Lancet. 2006 Jan 21; 367(9506):241-51. https://www.ncbi.nlm.nih.gov/pubmed/?term=16427494.
  4. Goldoni M, Bonini S, Urban ML, Palmisano A, De Palma G, Galletti E, Coggiola M, Buzio C, Mutti A, Vaglio A. Asbestos and smoking as risk factors for idiopathic retroperitoneal fibrosis: a case-control study. Ann Intern Med. 2014 Aug 5; 161(3):181-8. http://www.ncbi.nlm.nih.gov/pubmed/25089862.


Other Names for this Disease
  • Idiopathic retroperitoneal fibrosis
  • Ormond's disease
  • IgG4-related retroperitoneal fibrosis
  • Ormond disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.