Clear cell renal cell carcinoma
- Clear cell RCC
- Cystic-multilocular variant
- Clear-cell metastatic renal cell carcinoma (subtype)
Your QuestionI have read that IL-2 is no longer the standard treatment for metastatic clear cell renal cell carcinoma. According to the literature, it is no longer used in Europe. Is this true in North America? Is sunitinib now prescribed as treatment in North America?
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Questions on this page
IL-2 is offered as a treatment for this disease in some individuals because it has been shown to cause a complete disappearance of signs of this disease (remission) in 5% of treated patients. As IL-2 may cause toxic side effects, it is most appropriate for patients who are in excellent health.
Sunitinib is offered because it has been shown to stabilize metastatic clear cell renal cell carcinoma by stopping the disease from getting worse. Individuals treated with sunitinib showed no change in their disease for an average of 11 months.
The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. Currently, 38 clinical trials are identified as enrolling individuals with metastatic clear cell renal cell carcinoma. To find these trials, click on the link in the previous sentence. After you click on a study, review its "eligibility" criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.
You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH). We recommend calling 1-800-411-1222 to speak with a specialist, who can help you determine if you are eligible for any clinical trials. If you are located outside the United States, and would like to be contacted via telephone, you will need to contact PRPL and provide your telephone number in full, including area code and international dialing prefix.
Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Web site: http://clinicalcenter.nih.gov/
If you are interested in enrolling in a clinical trial, you can find helpful general information on clinical trials at the ClinicalTrials.gov Web page. Resources on many charitable or special-fare flights to research and treatment sites and low-cost hospitality accommodations for outpatients and family members, as well as ambulance services, are listed on the Web site of the Office of Rare Diseases Research (ORDR), part of the National Institutes of Health.
- National Comprehensive Cancer Network. Kidney Cancer. NCCN Clinical Practic Guidelines in Oncology. 2012; http://www.nccn.org/professionals/physician_gls/pdf/kidney.pdf. Accessed 5/31/2012.
- National Cancer Institute. Stage IV and Recurrent Renal Cell Cancer. Renal Cell Cancer Treatment. 2012; http://www.cancer.gov/cancertopics/pdq/treatment/renalcell/HealthProfessional/page8. Accessed 5/31/2012.