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Diseases

Genetic and Rare Diseases Information Center (GARD)

Clear cell renal cell carcinoma


Other Names for this Disease
  • Clear cell RCC
  • Cystic-multilocular variant
  • Clear-cell metastatic renal cell carcinoma (subtype)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

Newline Maker

What treatments for metastatic clear cell renal cell carcinoma are available in North America?

There are several treatments for metastatic clear cell renal cell carcinoma available in North America.  IL-2 and sunitinib - as well as the medications temsirolimus, bevacizumab with interferon therapy, pazopanib, and sorafenib - are approved by the Food and Drug Administration for the treatment of metastatic clear cell renal cell carcinoma.[1]  Because a cure for this disease has yet to be discovered, the National Cancer Institute suggests that individuals with metastatic clear cell renal cell carcinoma consider participation in a research study.[2]

IL-2 is offered as a treatment for this disease in some individuals because it has been shown to cause a complete disappearance of signs of this disease (remission) in 5% of treated patients.[2]  As IL-2 may cause toxic side effects, it is most appropriate for patients who are in excellent health.[1] 

Sunitinib is offered because it has been shown to stabilize metastatic clear cell renal cell carcinoma by stopping the disease from getting worse.  Individuals treated with sunitinib showed no change in their disease for an average of 11 months.[2]
Last updated: 6/1/2012

References
  1. National Comprehensive Cancer Network. Kidney Cancer. NCCN Clinical Practic Guidelines in Oncology. 2012; http://www.nccn.org/professionals/physician_gls/pdf/kidney.pdf. Accessed 5/31/2012.
  2. National Cancer Institute. Stage IV and Recurrent Renal Cell Cancer. Renal Cell Cancer Treatment. 2012; http://www.cancer.gov/cancertopics/pdq/treatment/renalcell/HealthProfessional/page8. Accessed 5/31/2012.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Clear cell renal cell carcinoma. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Sorafenib
Trade Name
(Manufacturer Name)
Nexavar®
(Bayer HealthCare Pharmaceuticals)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with advanced renal cell carcinoma
More Information about this product Drug Information Portal

Generic Name Aldesleukin
Trade Name
(Manufacturer Name)
Proleukin®
(Novartis)
Indication
The FDA has approved this product to be used in this manner.
Treatment of adults (>18 years old) with metastatic renal cell carcinoma.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Temsirolimus
Trade Name
(Manufacturer Name)
Torisel®
(Wyeth Pharmaceuticals, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of advanced renal cell carcinoma
More Information about this product Drug Information Portal
Medline Plus Health Information

Other Names for this Disease
  • Clear cell RCC
  • Cystic-multilocular variant
  • Clear-cell metastatic renal cell carcinoma (subtype)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.