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Diseases

Genetic and Rare Diseases Information Center (GARD)

Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency


Other Names for this Disease
  • LOCAH
  • Non classic congenital adrenal hyperplasia
  • NCCAH
  • Attenuated congenital adrenal hyperplasia
Related Diseases
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Treatment

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How might non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency be treated?

In some cases, people affected by non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NCAH) may not require any treatment. Many are asymptomatic throughout their lives, although symptoms may develop during puberty, after puberty, or post partum. If symptoms are present, a glucocorticoid called dexamethasone is often recommended. Dexamethasone can treat irregular menstruation, acne, and excess body hair (hirsutism).[1][2]
Last updated: 10/19/2015

References
  1. Merke DP & Nieman LK. Diagnosis and treatment of nonclassic (late-onset) congenital adrenal hyperplasia due to 21-hydroxylase deficiency. UpToDate. September 16, 2014; http://www.uptodate.com/contents/diagnosis-and-treatment-of-nonclassic-late-onset-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency. Accessed 7/6/2015.
  2. Saroj Nimkarn, MD and Maria I New, MD. 21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia. GeneReviews. August 2013; http://www.ncbi.nlm.nih.gov/books/NBK1171/.


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Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • LOCAH
  • Non classic congenital adrenal hyperplasia
  • NCCAH
  • Attenuated congenital adrenal hyperplasia
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.