Acquired amegakaryocytic thrombocytopenia
Other Names for this Disease
- Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
- Acquired pure megakaryocytic aplasia
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thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds. There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people.Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe
Last updated: 10/26/2015
- Brown GE, Babiker HM, Cantu CL, Yeager AM, Krishnadasan R.. "Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. Case Rep Hematol. 2014. 2014; Accessed 10/26/2015.
- Patel M, Kalra A, Surapaneni R, Schwarting R, Devereux L. Acquired amegakaryocytic thrombocytopenia in a patient with occupational chemical exposure. Am J Ther. January-February 2014; 21(1):e17-20.
- Thrombocytopenia. National Heart, Lung, and Blood Institute. September 2012; http://www.nhlbi.nih.gov/health/health-topics/topics/thcp.
- Thrombocytopenia. MedlinePlus. February 2014; https://www.nlm.nih.gov/medlineplus/ency/article/000586.htm.
- The National Heart Lung and Blood Institute (NHLBI) provides information on thrombocytopenia in general. The NHLBI was created to conduct research and distribute health information on diseases of the heart, blood vessels, lungs, and blood.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired amegakaryocytic thrombocytopenia. Click on the link to view a sample search on this topic.