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Diseases

Genetic and Rare Diseases Information Center (GARD)

Acquired amegakaryocytic thrombocytopenia


Other Names for this Disease
  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
  • AAT
  • Acquired pure megakaryocytic aplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent.[1][2] Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds.[3][4] There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people.[1][2] 
Last updated: 10/26/2015

References

  1. Brown GE, Babiker HM, Cantu CL, Yeager AM, Krishnadasan R.. "Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. Case Rep Hematol. 2014. 2014; Accessed 10/26/2015.
  2. Patel M, Kalra A, Surapaneni R, Schwarting R, Devereux L. Acquired amegakaryocytic thrombocytopenia in a patient with occupational chemical exposure. Am J Ther. January-February 2014; 21(1):e17-20.
  3. Thrombocytopenia. National Heart, Lung, and Blood Institute. September 2012; http://www.nhlbi.nih.gov/health/health-topics/topics/thcp.
  4. Thrombocytopenia. MedlinePlus. February 2014; https://www.nlm.nih.gov/medlineplus/ency/article/000586.htm.
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Basic Information

  • The National Heart Lung and Blood Institute (NHLBI) provides information on thrombocytopenia in general. The NHLBI was created to conduct research and distribute health information on diseases of the heart, blood vessels, lungs, and blood.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired amegakaryocytic thrombocytopenia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
  • AAT
  • Acquired pure megakaryocytic aplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.