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Diseases

Genetic and Rare Diseases Information Center (GARD)

Acquired amegakaryocytic thrombocytopenia


Other Names for this Disease
  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
  • AAT
  • Acquired pure megakaryocytic aplasia
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Treatment

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How might acquired amegakaryocytic thrombocytopenia be treated?

Standard treatment guidelines have not been established for acquired amegakaryocytic thrombocytopenia. However, various immunosuppressive treatment approaches have been utilized in affected people. In several case reports, affected people were successfully treated with cyclosporine either alone or in combination with other immunosuppressive medications (i.e. antithymocyte globulin). Other therapies for acquired amegakaryocytic thrombocytopenia have included rituximab, danazol, azathioprine, and bone marrow transplant with variable success.[1]

To determine the best treatment for you or a family member, please speak with a healthcare provider.
Last updated: 10/26/2015

References
  1. Brown GE, Babiker HM, Cantu CL, Yeager AM, Krishnadasan R.. "Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. Case Rep Hematol. 2014. 2014; Accessed 10/26/2015.


GARD Video Tutorial

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Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Acquired amegakaryocytic thrombocytopenia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
  • AAT
  • Acquired pure megakaryocytic aplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.