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Diseases

Genetic and Rare Diseases Information Center (GARD)

Tylosis


Other Names for this Disease
  • Hyperkeratosis of the palms and soles and esophageal papillomas
  • Focal non epidermolytic palmoplantar keratoderma
  • Familial tylosis (subtype)
  • Late onset tylosis (type A)
  • Early onset tylosis (type B)
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Overview

Tylosis is a rare genetic disorder characterized by hyperkeratosis of the palms of the hands and soles of the feet. Hyperkeratosis is an overgrowth of the outer skin layer (epidermis). The hyperkeratosis may be limited to pressure-bearing areas or cover the entire surface of the palms and soles. The degree and pattern of involvement can vary between the hands and feet of the same individual, within families, and among families. Tylosis is inherited in an autosomal dominant pattern.[1][2][3]

Two types of tylosis have been described, a late onset form and an early onset form. Late onset tylosis (type A) occurs between the ages of 5 and 15 and is reported to be associated with a high incidence of esophageal cancer. Early onset tylosis (type B) occurs in the first year of life and appears to be a benign disorder. Distinguishing between the two is important for management and prognosis.[1]
Last updated: 4/26/2016

References

  1. Maillefer RH, Greydanus MP. To B or not to B: is tylosis B truly benign? Two North American genealogies. American Journal of Gastroenterology. 1999 Mar; 94(3):829-34. http://www.ncbi.nlm.nih.gov/pubmed/10086674.
  2. Ellis A, Risk JM, Maruthappu T, Kelsell DP. Tylosis with oesophageal cancer: Diagnosis, management and molecular mechanisms. Orphanet J Rare Dis. 2015 Sep 29; 10:126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589029/.
  3. Stanway A. Palmoplantar keratoderma. DermNet NZ. September 21, 2015; http://www.dermnetnz.org/scaly/palmoplantar-keratoderma.html.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Tylosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hyperkeratosis of the palms and soles and esophageal papillomas
  • Focal non epidermolytic palmoplantar keratoderma
  • Familial tylosis (subtype)
  • Late onset tylosis (type A)
  • Early onset tylosis (type B)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.