Multicentric Castleman Disease
Other Names for this Disease
- Idiopathic multicentric Castleman's disease
- Multicentric angiofollicular ganglionic hyperplasia
- Multicentric angiofollicular lymph hyperplasia
- Multicentric Castleman's disease
Your QuestionHow might multicentric Castleman's disease be treated?
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The treatment of multicentric Castleman disease (MCD) varies based on the severity of the condition and whether or not the patient has an HIV and/or human herpes virus type 8 (HHV-8) infection. Possible treatment options include:
- Immunotherapy can be used to block the action of the interleukin-6 (IL-6), a protein that is produced in excess by the immune system of people with MCD
- Chemotherapy may be recommended to slow the growth of lymphatic cells
- Corticosteroid medications can reduce inflammation
- Anti-viral drugs can block the activity of HHV-8 or HIV (in people who are infected by these viruses)
Last updated: 6/25/2015
- Castleman Disease. American Cancer Society. July 2014; http://www.cancer.org/cancer/castlemandisease/detailedguide/index.
- Neetu Radhakrishnan, MD. Castleman Disease. Medscape Reference. January 2015; http://emedicine.medscape.com/article/2219018-overview.
- Jon C Aster, MD; Jennifer R Brown, MD, PhD; Nikhil C Munshi, MD. Multicentric Castleman's disease. UpToDate. January 2015; Accessed 6/25/2015.