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Diseases

Genetic and Rare Diseases Information Center (GARD)

Multicentric Castleman Disease


Other Names for this Disease
  • MCD
  • Plasmablastic multicentric Castleman disease
  • PMCD
  • Multicentric plasma cell variant of Castleman's disease
  • Idiopathic multicentric Castleman's disease
Related Diseases
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Overview

Multicentric Castleman disease (MCD) is a rare condition that affects the lymph nodes and related tissues. It is a form of Castleman disease that is "systemic" and affects multiple sets of lymph nodes and other tissues throughout the body (as opposed to unicentric Castleman disease which has more "localized" effects). The signs and symptoms of MCD are often nonspecific and blamed on other, more common conditions. They can vary but may include fever; weight loss; fatigue; night sweats; enlarged lymph nodes; nausea and vomiting; and an enlarged liver or spleen. The eact underlying cause is unknown. Treatment may involve immunotherapy, chemotherapy, corticosteroid medications and/or anti-viral drugs.[1][2][3]
Last updated: 6/25/2015

References

  1. Castleman Disease. American Cancer Society. July 2014; http://www.cancer.org/cancer/castlemandisease/detailedguide/index.
  2. Neetu Radhakrishnan, MD. Castleman Disease. Medscape Reference. January 2015; http://emedicine.medscape.com/article/2219018-overview.
  3. Jon C Aster, MD; Jennifer R Brown, MD, PhD; Nikhil C Munshi, MD. Multicentric Castleman's disease. UpToDate. January 2015; Accessed 6/25/2015.
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Basic Information

  • The American Cancer Society provides detailed information about Multicentric Castleman Disease. Click on the link to access this information. 
  • Mayo Clinic has an information page on Multicentric Castleman Disease.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Multicentric Castleman Disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • MCD
  • Plasmablastic multicentric Castleman disease
  • PMCD
  • Multicentric plasma cell variant of Castleman's disease
  • Idiopathic multicentric Castleman's disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.