Multicentric Castleman Disease
Other Names for this Disease
- Plasmablastic multicentric Castleman disease
- Multicentric plasma cell variant of Castleman's disease
- Idiopathic multicentric Castleman's disease
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The treatment of multicentric Castleman disease (MCD) varies based on the severity of the condition and whether or not the patient has an HIV and/or human herpes virus type 8 (HHV-8) infection. Possible treatment options include:
- Immunotherapy can be used to block the action of the interleukin-6 (IL-6), a protein that is produced in excess by the immune system of people with MCD
- Chemotherapy may be recommended to slow the growth of lymphatic cells
- Corticosteroid medications can reduce inflammation
- Anti-viral drugs can block the activity of HHV-8 or HIV (in people who are infected by these viruses)
Last updated: 6/25/2015
- Castleman Disease. American Cancer Society. July 2014; http://www.cancer.org/cancer/castlemandisease/detailedguide/index.
- Neetu Radhakrishnan, MD. Castleman Disease. Medscape Reference. January 2015; http://emedicine.medscape.com/article/2219018-overview.
- Jon C Aster, MD; Jennifer R Brown, MD, PhD; Nikhil C Munshi, MD. Multicentric Castleman's disease. UpToDate. January 2015; Accessed 6/25/2015.
- ClinicalTrials.gov lists trials that are studying or have studied Multicentric Castleman Disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
- The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
(Janssen Biotech, Inc.)
The FDA has approved this product to be used in this manner.
|Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.|
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