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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lattice corneal dystrophy type 1


Other Names for this Disease
  • Corneal dystrophy, lattice type 1
  • CDL1
  • LCD1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Lattice corneal dystrophy type 1 (LCD1) is an eye disorder that affects the cornea, the clear outer covering of the eye. In order to see properly, the cornea must remain clear. In LCD1, a protein, known as amyloid, builds up in a layer of the cornea called the stroma.   Symptoms usually become apparent in childhood or adolescence and may include separation of layers of the cornea (corneal erosions), decreased vision, photosensitivity, and eye pain. LCD1 is caused by mutations in the TGFBI gene and is inherited in an autosomal dominant manner. Treatment focuses on relieving erosions with antibiotics and bandage contact lenses. If treatment is not successful and erosions become recurrent, phototherapeutic keratectomy to smooth the corneal surface and corneal transplant may be considered.[1][2]
Last updated: 5/13/2016

References

  1. Natalie A Afshari, Stuart I Brown. Lattice Corneal Dystrophy. Medscape. Sep 22, 2014; http://emedicine.medscape.com/article/1193793-overview.
  2. lattice corneal dystrophy type I. Genetics Home Reference. April 2012; https://ghr.nlm.nih.gov/condition/lattice-corneal-dystrophy-type-i.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Lattice corneal dystrophy type 1. This website is maintained by the National Library of Medicine.
  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lattice corneal dystrophy type 1. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Corneal dystrophy, lattice type 1
  • CDL1
  • LCD1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.