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Genetic and Rare Diseases Information Center (GARD)

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Meesmann corneal dystrophy


Other Names for this Disease
  • Corneal dystrophy, juvenile epithelial of Meesmann
  • Juvenile hereditary epithelial dystrophy
  • Juvenile hereditary epithelial dystrophy of Meesmann
  • MECD
  • Meesman dystrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Meesmann corneal dystrophy is a rare genetic condition affecting the epithelial membrane of the cornea. A slit-lamp examination of the cornea shows diffuse clusters of tiny round cysts in the epithelial membrane.  Over time these cysts can rupture and cause erosions. The erosions may result in light sensitivity, redness, and pain. Vision remains good in most, but not all, cases. Meesmann corneal dystrophy can be caused by mutations in the KRT3 or KRT12 gene. It is inherited in an autosomal dominant fashion. 

Last updated: 5/22/2015

References

  1. Meesmann corneal dystrophy. Genetics Home Reference. 08/2012; http://ghr.nlm.nih.gov/condition/meesmann-corneal-dystrophy. Accessed 5/22/2015.
  2. Gordon K Klintworth. Corneal dystrophies. Orphanet Journal of Rare Diseases. 23 February 2009; 4:7:http://www.ojrd.com/content/4/1/7. Accessed 5/22/2015.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Meesmann corneal dystrophy. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Meesmann corneal dystrophy. Click on the link to view a sample search on this topic.

Diagrams/Images

  • A diagram of the eye can be found by visiting MedlinePlus, the National Library of Medicine Web site designed to help you research your health questions. Click on MedlinePlus to view the diagram.
Other Names for this Disease
  • Corneal dystrophy, juvenile epithelial of Meesmann
  • Juvenile hereditary epithelial dystrophy
  • Juvenile hereditary epithelial dystrophy of Meesmann
  • MECD
  • Meesman dystrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.