Ossification of the posterior longitudinal ligament of the spine
* Not a rare disease
Other Names for this Disease
calcification of the soft tissues that connect the bones of the spine, which may lead to compression of the spinal cord. Many affected people do not have any signs or symptoms, while others may experience mild pain or numbness in the arms and/or legs. In some cases, OPLL may be associated with other conditions such as genetic diseases (i.e. hypophosphatemic rickets), endocrine disorders (i.e. acromegaly, hypoparathyroidism), spondyloarthropathies (i.e. ankylosing spondylitis), and diffuse idiopathic skeletal hyperostosis. OPLL is most commonly diagnosed in men, people of Asian descent and people over age 50. The exact underlying cause is currently unknown; however, scientists suspect that it is a multifactorial condition that is influenced by several different genetic and environmental factors. The treatment of OPLL depends the severity of the condition and the signs and symptoms present in each person. If more conservative treatments such as NSAIDs are not effective, surgery may be necessary.Ossification of the posterior longitudinal ligament of the spine (OPLL) is a condition that is characterized by the
Last updated: 5/4/2015
- Andrew Eisen, MD, FRCPC. Disorders affecting the spinal cord. UpToDate. October 2014; Accessed 5/4/2015.
- Simon M Helfgott, MD. Diffuse idiopathic skeletal hyperostosis (DISH). UpToDate. December 2013; Accessed 5/4/2015.
- Ikegawa S. Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review. J Bone Metab. May 2014; 21(2):127-132.
- Emory Healthcare offers an information page on Ossification of the posterior longitudinal ligament of the spine for patients and caregivers. Please click on the link to access this resource.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
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