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Genetic and Rare Diseases Information Center (GARD)

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Familial cylindromatosis


Other Names for this Disease
  • CYLD
  • Cylindromatosis, familial
  • Turban tumor syndrome
  • Turban tumors
Related Diseases
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Overview

Familial cylindromatosis is a condition that causes multiple  non-cancerous ( benign tumors called cylindromas to develop from the skin on  the head and neck.[1]  These tumors rarely become cancerous (malignant ).  Many, rounded nodules of various size begin to develop shortly after puberty. They tend to grow very slowly and increase in number over time, and may be significantly affect appearance or cause vision difficulties.[1]  Individuals with this condition also have an increased chance to develop other skin tumors and tumors in the salivary gland.[1]  

Familial cylindromatosis is 
inherited  in an autosomal dominant manner and is associated with mutations in the CYLD gene.[1][2]
Last updated: 2/18/2015

References

  1. Scheinfeld NS. Cylindroma. Medscape Reference. January 13, 2015; http://emedicine.medscape.com/article/1056630-overview#a0101. Accessed 2/18/2015.
  2. Familial cylindromatosis. Genetics Home Reference. June, 2012; http://ghr.nlm.nih.gov/condition/familial-cylindromatosis. Accessed 2/18/2015.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Familial cylindromatosis. This website is maintained by the National Library of Medicine.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial cylindromatosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • CYLD
  • Cylindromatosis, familial
  • Turban tumor syndrome
  • Turban tumors
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.