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Diseases

Genetic and Rare Diseases Information Center (GARD)

Familial atrial fibrillation


Other Names for this Disease
  • Atrial fibrillation autosomal dominant
  • Autosomal dominant atrial fibrillation
  • Atrial fibrillation, familial
  • ATFB
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Familial atrial fibrillation is an inherited heart condition that disrupts the heart's rhythm. It is characterized by erratic electrical activity in the heart's upper chambers (the atria), causing an irregular response in the heart's lower chambers (the ventricles). This causes a fast and irregular heartbeat (arrhythmia). Signs and symptoms may include dizziness, chest pain, palpitations, shortness of breath, or fainting. Affected people also have an increased risk of stroke and sudden death. While complications may occur at any age, some affected people never have associated health problems.[1] Familial atrial fibrillation may be caused by changes (mutations) in any of various genes, some of which have not been identified. It is most often inherited in an autosomal dominant manner, but autosomal recessive inheritance has been reported.[2]
Last updated: 11/9/2015

References

  1. Familial atrial fibrillation. Genetics Home Reference. January, 2007; http://ghr.nlm.nih.gov/condition/familial-atrial-fibrillation.
  2. Oscar Campuzano and Ramon Brugada. Genetics of familial atrial fibrillation. Europace. October, 2009; 11(10):1267-1271.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Familial atrial fibrillation. This website is maintained by the National Library of Medicine.
  • The National Heart, Lung, and Blood Institute (NHLBI) has information on this topic. NHLBI is part of the National Institutes of Health and supports research, training, and education for the prevention and treatment of heart, lung, and blood diseases.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial atrial fibrillation. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Atrial fibrillation autosomal dominant
  • Autosomal dominant atrial fibrillation
  • Atrial fibrillation, familial
  • ATFB
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.