Limited systemic sclerosis
Other Names for this Disease
- Limited systemic sclerosis
- Progressive systemic sclerosis sine scleroderma
- Scleroderma, sine
- Systemic sclerosis sine scleroderma
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systemic scleroderma that is characterized by Raynaud's phenomenon and the buildup of scar tissue (fibrosis) on one or more internal organs but not the skin. While the exact cause of sine scleroderma is unknown, it is believed to originate from an autoimmune reaction which leads to the overproduction of collagen (a tough protein which normally strengthens and supports connective tissues throughout the body). When fibrosis affects internal organs, it can lead to impairment or failure of the affected organs. The most commonly affected organs are the esophagus, heart, lungs, and kidneys. Internal organ involvement may be signaled by heartburn, difficulty swallowing (dysphagia), high blood pressure (hypertension), kidney problems, shortness of breath, diarrhea, or impairment of the muscle contractions that move food through the digestive tract (intestinal pseudo-obstruction).Sine scleroderma is a type of
Last updated: 1/30/2013
- Systemic scleroderma. Genetics Home Reference (GHR). September 2011; http://ghr.nlm.nih.gov/condition/systemic-scleroderma. Accessed 1/30/2013.
- Handout on Health: Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). August 2012; http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed 1/30/2013.
- Hachulla E. Limited systemic sclerosis. Orphanet. July 2010; http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=18907. Accessed 1/30/2013.
- Genetics Home Reference (GHR) contains information on Limited systemic sclerosis. This website is maintained by the National Library of Medicine.
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- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Limited systemic sclerosis. Click on the link to view a sample search on this topic.
- Select volumes of the Scleroderma Care and Research Jounal can be viewed by visiting the Scleroderma Clinical Trials Consortium Web site. Click on the link above to learn more.