Other Names for this Disease
- Hereditary white nails
- Porcelain nails
- Nail disorder, nonsyndromic congenital, 3
- Total leukonychia
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 It is usually inherited in an autosomal dominant manner. Less commonly, it may be inherited in an autosomal recessive manner, or acquired (not inherited) during a person's lifetime. The inherited forms can be caused by mutations in the PLCD1 gene and generally involve the entire plate of all 20 nails. In some cases, leukonychia totalis has been associated with various other abnormalities or syndromes. Treatment may focus on the underlying cause when it is associated with another condition.Leukonychia totalis is a nail condition characterized by complete whitening of the entire nail plate.
Last updated: 2/18/2014
- Howard SR, Siegfried EC. A case of leukonychia. J Pediatr. September, 2013; 163(3):914-915. Accessed 2/18/2014.
- Yalçin Tüzün, Özge Karakus. Leukonychia. J Turk Acad Dermatol. 2009; 3(1):Accessed 2/18/2014.
- Marla J. F. O'Neill. NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3; NDNC3. OMIM. August 11, 2011; http://omim.org/entry/151600. Accessed 2/18/2014.
On this page
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Leukonychia totalis. Click on the link to view a sample search on this topic.