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Diseases

Genetic and Rare Diseases Information Center (GARD)

Dowling-Degos disease


Other Names for this Disease
  • Reticulate acropigmentation of Kitamura
  • Reticular pigment anomaly of flexures
  • Dowling-Degos Kitamura disease
  • Kitamura reticulate acropigmentation
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Treatment

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Is there a medicine that can cure Dowling-Degos disease?

There is no cure for Dowling-Degos disease.[1][2][3] Many different treatments have been tried for this condition, but none has proven effective in eliminating the symptoms for all patients. Topical retinoic acids, topical steroids, hydroquinone, tretinoin, and systemic retinoids have been used without success.[1] Limited reports indicate at least temporary therapeutic benefit with topical adapalene. Various laser systems (CO2 and erbiumYAG) have also shown some promise.[2][3]   

Additional articles that address this topic can be accessed below:

Wenzel G, Petrow W, Tappe K, Gerdsen R, Uerlich WP, Bieber T. Treatment of Dowling-Degos disease with Er:YAG-laser: results after 2.5 years. Dermatol Surg. 2003 Nov;29(11):1161-2.

Wenzel J, Tappe K, Gerdsen R, Uerlich M, Philipp-Dormston W, Bieber T, Petrow W. Successful treatment of Dowling-Degos disease with Er:YAG laser. Dermatol Surg. 2002 Aug;28(8):748-50.

Altomare G, Capella GL, Fracchiolla C, Frigerio E. Effectiveness of topical adapalene in Dowling-Degos disease. Dermatology. 1999;198(2):176-7. 

Last updated: 2/4/2013

References
  1. Schwartz RA. Reticulate Pigmented Anomaly . Medscape Reference. May 2012; http://emedicine.medscape.com/article/1118586-overview. Accessed 2/4/2013.
  2. Kang HS, Hur J, Lee JW, Oh DH, Yeo KY, Kim JS, Yu HJ. A Case of Dowling-Degos Disease on the Vulva. Ann Dermatol. May 2011; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130865/. Accessed 2/4/2013.
  3. Horner ME, Parkinson KE, Kaye V, Lynch PJ. Dowling-Degos Disease involving the vulva and back: Case report and review of the literature . Dermatology Online Journal. July 2011; http://dermatology.cdlib.org/1707/2_csr/1_11-00143/article.html. Accessed 2/4/2013.


GARD Video Tutorial

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Other Names for this Disease
  • Reticulate acropigmentation of Kitamura
  • Reticular pigment anomaly of flexures
  • Dowling-Degos Kitamura disease
  • Kitamura reticulate acropigmentation
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.